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KMID : 0360220110520091055
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Journal of the Korean Ophthalmological Society
2011 Volume.52 No. 9 p.1055 ~ p.1062
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Electroretinographic Assessment of the Retinal Function during Intravitreal Bevacizumab Injections in Central Retinal Vein Occlusion
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Cho In-Hwan
Park Tae-Kwann
Ohn Young-Hoon
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Abstract
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Purpose:To investigate the changes of electroretinogram (ERG) at baseline and during the first 3 injections of intravitreal bevacizumab in central retinal vein occlusion (CRVO) patients.
Methods:Thirteen eyes of 13 CRVO patients who received 3 injections of intravitreal bevacizumab at 6-week intervals and who could be examined for visual acuity, optical coherence tomography and ERG at 4 weeks after each injection were included in the present study. In addition, the ERG results of the unaffected fellow eyes group at 4 weeks after each injection were compared with the CRVO eyes group.
Results:Amplitudes of rod b wave, a and b waves of maximal combined response and cone response, oscillatory potentials and 30-Hz flicker significantly decreased in the CRVO eyes group than the fellow eyes group at 4 weeks after each injection (p < 0.001). After injection, amplitudes of all the above-mentioned ERG parameters gradually increased during the 1st and the 2nd injection (p < 0.001). However, there was no significant difference at 4 weeks after the 2nd and 3rd injections (p > 0.05).
Conclusions:After intravitreal bevacizumab injection, macular functions significantly improved and amplitudes of all ERG parameters gradually increased in CRVO patients.
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KEYWORD
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Central retinal vein occlusion, Electroretinogram, Intravitreal bevacizumab injection
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